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Low carb high-fat diet helps against diabetic kidney disease

Thu, 21 Apr 2011

A study by scientists in the United States has found that regularly consuming a low carbohydrate, high-fat diet can reverse diabetic kidney damage, it has emerged.

The research, involving tests on mice at the Mount Sinai School of Medicine in New York, revealed that the ketogenic diet can successfully reversing the effects of diabetic kidney disease (or nephropathy) in mice that have either type 1 or type 2 diabetes .

It was known that a specific ketone, 3-beta-hydroxybutyric acid (3-OHB), is able to lower cell response to glucose, and the team assessed if a high-fat diet was able to reverse the effects of diabetic nephropathy . After two months of trials, the ketogenic diet was found to lower the ratio of albumin to creatinine, which is a common measurement for levels of kidney damage .

Lead author of the study, entitled "Reversal of Diabetic Nephropathy by a Ketogenic Diet", Charles Mobbs, commented "Our study is the first to show that a dietary intervention alone is enough to reverse this serious complication of diabetes ."

The researchers also claim that the ketogenic diet could provide benefits to people suffering from related diabetic complications including retinopathy and neuropathy. However, they are also aware that it is a difficult diet to maintain, but argue that even exposure to the diet for a month can offer some re-setting of the gene expression and pathological process that can bring on kidney failure .
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